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Beilstein J. Org. Chem. 2015, 11, 763–772, doi:10.3762/bjoc.11.86
Graphical Abstract
Scheme 1: Synthesis of multivalent arginine and histidine functionalized dPG-NH2 50%. The depicted dPG-NH2 re...
Figure 1: Agarose gel electrophoresis retardation assay of AAdPGs/siRNA polyplexes. (A) dPG-13Arg13His, (B) d...
Figure 2: Size measurements of dPG-NH2 50% and AAdPGs/siRNA complexes. Intensity distributions of all polyple...
Figure 3: The result of MTT assay on a NIH 3T3 cell line transfected with AAdPG, dPG-NH2 50%, and 90%/siRNA p...
Figure 4: Cell viability versus transfection efficiency of dPG-8Arg30His and dPG-NH2 90% at N/P ratio 30.
Figure 5: Summary of transfection results versus viability of AAdPGs with various Arg and His composition rat...
Figure 6: Confocal images of NIH 3T3 cells treated with Cy3-siRNA/vector complexes: (A) naked siRNA, (B) lipo...